IGF-1 LR3
Long-acting IGF-1 analog studied for IGF-1 receptor signaling in growth and tissue-recovery models.
This product is not a drug, food, or cosmetic and is not intended to diagnose, treat, cure, or prevent any disease. Not for human or veterinary use. By purchasing, you confirm you are a qualified researcher or institution acquiring this product solely for in-vitro laboratory research. See our Research Disclaimer for full terms.
Description
IGF-1 LR3 is an 83-amino acid analog of insulin-like growth factor 1, modified with a substituted B-chain and a 13-amino acid extension (the 'Long R3' domain) that reduces binding affinity to IGF-binding proteins, extending its active plasma half-life relative to native IGF-1. Research on the analog has focused on sustained activation of the IGF-1 receptor tyrosine kinase, engaging PI3K-Akt and Ras-MAPK signaling cascades associated with cell proliferation, protein synthesis, and tissue-recovery models. It is frequently used as a research tool to isolate IGF-1 receptor signaling from confounding IGFBP interactions. Supplied for in-vitro laboratory research only — not for human or veterinary use.